1 |
EGF binds EGFR201. |
2 |
EGF-induced dimerization of EGFR via EGFR-EGFR interaction201
|
3 |
EGFR autophosphorylation at Y1016204
|
4 |
EGFR autophosphorylation at Y1092205
|
5 |
EGFR autophosphorylation at Y1110206
|
6 |
EGFR autophosphorylation at Y1172205
|
7 |
EGFR autophosphorylation at Y1197205
|
8 |
EGFR-mediated phosphorylation of Y317 in SHC1 (isoform p52Shc)207
|
9 |
EGFR-mediated phosphorylation of Y627 in GAB1208
|
10 |
EGFR-mediated phosphorylation of Y659 in GAB1208
|
11 |
PTPN11 binds pY1016 in EGFR209. |
12 |
The SH2 domains in RASA1 mediate interaction with pY1016 in EGFR78, 210. |
13 |
The SH2 domain in GRB2 binds pY1092 in EGFR121, 211, 212. |
14 |
The SH2 domain in GRB2 binds pY1110 in EGFR121, 211, 212. |
15 |
The PTB domain in SHC1 binds pY1172 in EGFR122, 212. |
16 |
The PTB domain in SHC1 binds pY1197 in EGFR122, 212. |
17 |
PTPN11-mediated dephosphorylation of pY1016 in EGFR210
|
18 |
The SH2 domain in GRB2 binds pY317 in SHC1 (isoform p52Shc)207. |
19 |
The N-terminal SH2 domain in PTPN11 binds pY627 in GAB1213. |
20 |
The C-terminal SH2 domain in PTPN11 binds pY659 in GAB1213. |
21 |
PTPN11-mediated dephosphorylation of pY627 in GAB1213
|
22 |
PTPN11-mediated dephosphorylation of pY659 in GAB1213
|
23 |
The GAP domain in RASA1 binds KRAS causing an increase in GTPase activity that favors the GDP-loaded form of KRAS214. |
24 |
The N-terminal SH3 domain in GRB2 interacts with several C-terminal proline-rich sequences (PRS) in SOS1215, 216. |
25 |
The C-terminal SH3 domain in GRB2 interacts with two central proline-rich sequences (PRS) in GAB1217. |
26 |
GTP-loaded KRAS binds the REM domain in SOS1, which increases the GEF activity of SOS1218, 219. |
27 |
The GEF domain in SOS1 binds KRAS causing a release of guanine nucleotide that favors the GTP-loaded form of KRAS220. |