Table 1. Distribution of SLCO1B1 single nucleotide polymorphisms in 12 healthy volunteers.
Characteristic | African American | Caucasian | Combined population |
---|---|---|---|
SLCO1B1c.388G→A (*1b) | |||
GG (reference) | 3 (50.0%) | 1 (16.7%) | 4 (33.3%) |
GA | 2 (33.3%) | 5 (83.3%) | 7 (58.3%) |
AA | 1 (16.7%) | 0 (0%) | 1 (8.3%) |
Allelic frequency % | 33.3% | 41.6% | 37.5% |
P value* | 0.4 | ||
SLCO1B1 rs4149032 (intron tSNP) | |||
TT (reference) | 2 (33.3%) | 1 (16.7%) | 3 (25.0%) |
TC | 2 (33.3%) | 3 (50%) | 5 (41.7%) |
CC | 2 (33.3%) | 2 (33.3%) | 4 (33.3%) |
Allelic frequency % | 50.0% | 58.3% | 54.2% |
P value* | 0.6 | ||
SLCO1B1 c.463C→A (*4) | |||
CC (reference) | 4 (66.7%) | 2 (33.3%) | 6 (50.0%) |
CA | 2 (33.3%) | 4 (66.7%) | 6 (50.0%) |
AA | 0 (0%) | 0 (0%) | 0 (0.0%) |
Allelic frequency % | 16.7% | 33.3% | 50.0.0% |
P value* | 0.2 | ||
SLCO1B1 c.521T→C (*5) | |||
TT (reference) | 5 (83.3%) | 2 (33.3%) | 7 (58.3%) |
TC | 0 (0.0%) | 4 (66.7%) | 4 (33.3%) |
CC | 1 (16.7%) | 0 (0.0%) | 1 (8.3%) |
Allelic frequency % | 8.3% | 16.7% | 25.0% |
P value* | 0.7 |
Chi square testing of Hardy-Weinberg equilibrium