Table 1.

Preventable and Non-Preventable Reasons for Discontinuation or Non-Adherence

Preventable	Non-Preventable
Low health literacy (patient did not understand instructions)	Serious mental illness (major depression; schizophrenia)
No-fill of first prescription identified	Serious side effects (e.g., diarrhea, weight gain, sleeplessness)
“Non-responder” or no clinical evidence of effectiveness of the medication	Serious adverse events (e.g., allergic reaction; renal toxicity)
Irregular refills obtained
Cost prohibitive for the patient