Table 1.
Summary of studies participating. Column 1 lists the acronym for each group, defined in the Supplementary Information (Dataset Descriptions). Column 2 indicates the number of subjects utilized for this meta-analysis. Columns 3 and 4 provide the mean age of initiation of tobacco (AOI) and onset of regular smoking (AOS) for groups that have those phenotypes. Columns 5–9 give minor allele frequencies at target SNPs for individual groups
| Datasets | N | AOI | AOS | Recruitment location | rs16969968 A | rs578776 T | rs588765 T | rs1948 A | rs684513 G |
|---|---|---|---|---|---|---|---|---|---|
| ACS-COPD | 2,791 | 19.2 | US | 0.35 | 0.27 | 0.42 | 0.34 | 0.21 | |
| ACS-LCA | 988 | 18 | US | 0.38 | 0.25 | 0.42 | 0.34 | – | |
| Add Health | 690 | 12.8 | 15.5 | US | 0.31 | 0.26 | 0.41 | 0.34 | 0.22 |
| ARIC | 5,775 | 18.5 | US | 0.34 | 0.28 | 0.42 | – | 0.21 | |
| BOMA | 828 | 18.1 | Germany | 0.36 | 0.27 | 0.41 | 0.34 | – | |
| CADD | 397 | 14 | 15.4 | US | 0.32 | 0.24 | 0.43 | 0.35 | 0.23 |
| COGA | 1,704 | 14.3 | 21.9 | US | 0.34 | 0.29 | 0.41 | – | – |
| COGEND | 2,057 | 13.3 | 15.5 | US | 0.35 | 0.27 | 0.42 | 0.33 | – |
| Dental Caries | 459 | 13.8 | US | 0.36 | 0.27 | 0.42 | 0.33 | – | |
| EAGLE-PLCO | 4,948 | 18 | Italy | 0.4 | 0.26 | 0.37 | 0.31 | – | |
| FINRISK | 7,542 | 21.6 | Finland | 0.33 | 0.32 | 0.38 | – | – | |
| GEOS | 475 | 16.9 | US | 0.37 | 0.3 | 0.39 | 0.31 | – | |
| KCI-WSU | 945 | 16.4 | US | 0.38 | – | – | – | – | |
| LHS-Utah | 1,943 | 17.4 | US | 0.39 | 0.24 | – | – | – | |
| LOLIPOP | 643 | 17.6 | UK | 0.31 | 0.31 | 0.43 | – | – | |
| MDACC LCA | 2,289 | 17.5 | US | 0.37 | 0.19 | 0.43 | 0.34 | 0.2 | |
| MDACC Melanoma | 825 | 18.6 | US | 0.33 | 0.27 | 0.44 | 0.35 | 0.23 | |
| MUC12 cases | 339 | 19.5 | Germany | 0.36 | 0.19 | 0.43 | 0.35 | – | |
| MUC12 controls | 216 | 20.1 | Germany | 0.34 | 0.21 | 0.43 | 0.32 | – | |
| MUCMD cases | 523 | 18.9 | Germany | 0.37 | 0.25 | 0.42 | 0.33 | 0.19 | |
| MUCMD controls | 989 | 20.2 | Germany | 0.35 | 0.27 | 0.42 | 0.32 | 0.21 | |
| NAG OZALC | 792 | 17 | Australia | 0.36 | 0.21 | 0.43 | 0.34 | – | |
| NAG FIN | 714 | 15.4 | 18.1 | Finland | 0.37 | 0.3 | 0.36 | 0.31 | – |
| NESDA | 1,138 | 16.3 | Netherlands | 0.31 | 0.3 | 0.38 | – | – | |
| NFBC1966 | 2,243 | 16.1 | 18.3 | Finland | 0.32 | 0.27 | 0.37 | 0.34 | – |
| NHS BRCA | 1,198 | 19.5 | US | 0.35 | 0.27 | 0.42 | 0.34 | – | |
| NHS CHD | 724 | 19.7 | US | 0.35 | 0.22 | 0.43 | – | – | |
| NHS T2D | 1,590 | 19.6 | US | 0.34 | 0.24 | 0.4 | – | – | |
| NTR1 | 464 | 16.2 | 18.7 | Netherlands | 0.31 | 0.17 | 0.9 | 0.33 | 0.28 |
| NTR2 | 593 | 15.9 | 18.1 | Netherlands | 0.31 | 0.3 | 0.46 | 0.36 | – |
| NYS-FS | 422 | 14.2 | 17 | US | 0.32 | 0.24 | 0.46 | 0.36 | 0.21 |
| QIMR | 258 | 16.4 | Australia | – | 0.29 | – | 0.34 | – | |
| SHIP | 1,871 | 18.5 | Germany | 0.34 | 0.22 | 0.43 | – | – | |
| SMOFAM | 398 | 17.8 | US | 0.32 | 0.28 | 0.46 | 0.38 | 0.18 | |
| STR | 4,096 | 18 | Sweden | 0.34 | 0.28 | – | 0.34 | – | |
| UTAH | 484 | 14.8 | 18 | US | 0.39 | 0.24 | – | – | – |
| VA-Twin | 1,960 | 14.4 | 16.5 | US | 0.33 | 0.28 | – | – | – |
| WTCCC-CHD | 1,219 | 17.7 | UK | 0.33 | 0.26 | 0.46 | – | – | |
| WTCCC-HT | 766 | 17.3 | UK | 0.31 | 0.31 | 0.44 | – | – | |
| Yale | 942 | 13.8 | 17.5 | US | 0.35 | 0.29 | – | – | 0.22 |
| YFS | 365 | 10.9 | 14.6 | Finland | 0.32 | 0.31 | 0.4 | 0.35 | – |