Fig. 1.

Infant versus adult retinal layers differences visualized by SDOCT. Summed SDOCT B-scans at the fovea. (A) From a 31-week-old PMA premature infant (born at 27 weeks PMA, birth weight 1205 g, ROP zone II, stage 2) and (B) from a 23-year-old adult born at term. (C, D) are magnified images of (A, B), respectively, to show retinal layers in better detail. From inner (top) to outer (bottom), the layers are nerve fiber layer, ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer, external limiting membrane, inner segment (IS) to outer segment (OS), photo-receptor OS, and retinal pigment epithelium (RPE) microvilli, and RPE. Note that the thick IRLs of the neonate (blue upper vertical line, layers listed in blue) correspond to thin condensed corresponding layers in the adult and that the thin outer retinal layers of the neonate (orange lower vertical line) became thicker layers in the adult eye (listed in orange; external limiting membrane [ELM], IS/OS, and OS/RPE were not present in the premature fovea). (From Maldonado RS, O’Connell RV, Sarin N, et al. Dynamics of human foveal development after premature birth. Ophthalmology 2011;118(12):2316; with permission.)