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. Author manuscript; available in PMC: 2014 Mar 9.
Published in final edited form as: Oncogene. 2012 Oct 8;32(36):4252–4263. doi: 10.1038/onc.2012.438

Figure 2. Enriched OSIC activities correlate with accelerated sphere formation and expression of stem/progenitor cell-associated genes.

Figure 2

(A) Microscopy analysis of spheres cultivated in suspension for 12 days. Representative phase-contrast micrographs of spheres were shown with 400x magnification. UT1 or UT2 vs. U2OS: *P<0.05; **P<0.01. (B) Up-regulated expressions of stem cell/progenitor marker genes in UT2 cells compared to parental U2OS cells. (C-H) Serial transplantation up-regulated expressions of signaling molecules in the Notch, Wnt, and TGFβ pathways. The color bar represents the expression ratio on a log-2 scale (UT2 vs. U2OS or MSC).

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