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. Author manuscript; available in PMC: 2014 Mar 9.
Published in final edited form as: Oncogene. 2012 Oct 8;32(36):4252–4263. doi: 10.1038/onc.2012.438

Figure 3. Enhanced OSIC self-renewal and tumorigenicity induce a progressive expansion of CD49f+ cells forming the osteosarcoma mass.

Figure 3

(A-C) Expression levels of CD59, CD28, CD43, CD117, CD133 and STRO-1 (panel A) as well as CD49f (panels B, C) were determined by FACS in U2OS, UT2 and UT3 cells. (D) FACS analysis of CD49f expression in normal (MSC), KHOS/NP, and 8 different primary osteosarcoma cells. (E & F) Inverse relationship between CD49f levels vs. time for tumor formation in serially transplanted (panel E) and the first transplanted cells (panel F).

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