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. Author manuscript; available in PMC: 2015 Feb 20.
Published in final edited form as: Mol Cell. 2014 Jan 23;53(4):577–590. doi: 10.1016/j.molcel.2013.12.018

Figure 5. Model of the regulation of FGFR-2 alternative splicing by IWS1 phosphorylation at Ser720/Thr721 by Akt1 or Akt3.

Figure 5

The phosphorylation of IWS1 attracts SetD2 to the Spt6/IWS1/Aly complex in the CTD of RNA Pol II. SetD2 in the complex trimethylates histone H3 at K36 during transcriptional elongation. MRG15 and its partner PTB bind histone H3K36me3. Binding of PTB to the IIIb exon promotes exclusion of this exon from the spliced transcript.