. Author manuscript; available in PMC: 2014 Nov 1.

Published in final edited form as: Bioorg Med Chem. 2013 Jul 23;21(21):6831–6843. doi: 10.1016/j.bmc.2013.07.028

Table 1.

Cytotoxicity against human cancer cell lines SK-OV-3, NCI-H460, and DU-145

GI₅₀ (µM) ± SD Sulforhodamine B assay^a
Compound	SK-OV-3	NCI-H460	DU-145
CA4	0.00533 ± 0.00180	0.00449 ± 0.0000648^b	0.00484 ± 0.000848^b
OXi8006	0.00345 ± 0.000409	0.0379 ± 0.00182	0.0356 ± 0.00107
25	4.35 ± 0.290	4.08 ± 0.119	5.52 ± 0.106
26	21.1 ± 2.45	16.8 ± 2.13	8.16 ± 4.41
27	2.65 ± 1.94	15.7 ± 1.64	7.11 ± 2.16
28	19.8 ± 3.95	5.54 ± 0.505	10.0 ± 9.83
29	15.0 ± 9.60	49.6 ± 3.20	10.0 ± 4.21
30	1.45 ± 0.365	2.86 ± 0.104	3.01 ± 0.0829
31	0.283 ± 0.0395	3.57 ± 0.508	2.99 ± 0.235
32	3.05 ± 0.895	2.35 ± 0.159	3.21 ± 0.294
33	2.167 ± 0.3657	2.910 ± 0.4833	3.401 ± 1.471
34	25.1 ± 0.262	41.8 ± 2.52	28.3 ± 18.0
35	0.264 ± 0.0418	0.177 ± 0.0245	0.309 ± 0.0143
36	0.0119 ± 0.00422	0.992 ± 0.320	0.0181 ± 0.000772

Average of n ≥ 3 independent determinations.

For additional data see refs. 15–16.