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Inhibition of tubulin polymerization and colchicine binding
| Inhibition of colchicine binding (%) ±SD |
|||
|---|---|---|---|
| Compound | Inhibition of tubulin polymerization IC50 (µM)±SD |
1 µM | 5µM |
| CA4 | 1.3±0.07 | 88±2 | 98±0.5 |
| OXi8006 | 1.1±0.04 | 40±0.2 | 75±0.2 |
| 25 | > 20 | nda | nd |
| 26 | > 20 | nd | nd |
| 27 | 19±0.8 | nd | 21±1 |
| 28 | 7.5±2 | nd | 26±2 |
| 29 | > 20 | nd | nd |
| 30 | 3.1±0.2 | nd | 26±2 |
| 31 | 3.7±0.4 | nd | 19±4 |
| 32 | > 20 | nd | nd |
| 33 | > 20 | nd | nd |
| 34 | > 20 | nd | nd |
| 35 | 1.0±0.1 | 51±0.4 | 85±0.7 |
| 36 | 1.1±0.4 | 31±4 | 67±3 |
nd = not determined in this study.
