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. Author manuscript; available in PMC: 2014 Mar 9.
Published in final edited form as: J Cell Physiol. 2008 Nov;217(2):502–510. doi: 10.1002/jcp.21526

Figure 7. Schematic of proposed Ets-1 signal pathway in response to shear stress stimulation.

Figure 7

Shear stress sensors transduce signals leading to ERK1/2 phosphorylation and Thr38 phosphorylation of Ets-1. Increased transcriptional activity of Ets-1 leads to expression of target genes, including Ets-1 itself, PAI-1, TIMP-1 and TIMP-3.