Table 1.

Timeline for Therapeutic Hypothermia After Pediatric Cardiac Arrest Trials

Year	Key Events
2002	PECARN originates and adult therapeutic hypothermia RCTs published New England Journal of Medicine
2003	National Institute of Child Health and Human Development R21 Request for Applications Pediatric Cardiac
	Arrest, Hypothermia RCT planning grant (HD044955) (July 2003) awarded
2004–2006	Cohort study conducted at 15 PECARN sites
2006	R34 (HD050531) awarded to support writing MOO (July 2006)
2006	Collaborative Pediatric Critical Care Research Network sites join PECARN sites to operationalize trials
	Protocol planning meeting in Washington, DC
	Other planning meetings in Toronto and Salt Lake City
2006	Prospective yield study at select sites using inclusion and exclusion criteria
2007	Draft MOO with “refined” protocol
	NHLBI contacted to submit application > ppg limit (1.5 M)
	Letter (5-page study overview) to directors NHLBI— approved
2008	R01s submitted (February 2008)
	Study section review and council approved
	Budget and study design modifications by NHLBI (November 2008)
2009	HL094345 and HL094339 awards received (March 2009)
	Institutional Review Board materials and contracts to sites (April 2009)
	Vanguard (half of sites) selection (June 2009)
	Training (August 2009)
	Enrollment begins per schedule (September 1, 2009)
	Data Safety and Monitoring Board created
2009	Vanguard site enrollment (September 2009–August 31, 2010)
	Exceeds feasibility (minimum) goal 50 cases and expected goal 75 cases
	Actual enrolled: 90 cases
2010	Funding approved to add second cohort of sites (September 2010)
2012	37 total sites and enrollment of 389 cases as of May 29, 2012

PECARN = Pediatric Emergency Care Applied Research Network, RCT = randomized controlled trials.