Fig. 4.
Relative isotopic enrichment in +1 molecular species of key TCA cycle intermediates identified in metabolic mutant C. elegans strains studied by isotope ratio mass spectrometry (IR/MS). Relative enrichment (percent atoms per excess, APE, corrected) was measured in molecular species of four organic acids by IR/MS in young adult worms fed 1,6-13C2-glucose throughout development. (A) Lactate, (B) Malate, (C) Succinate, and (D) Citrate. Symbols and p values are the same as described in the legend for Fig. 3. Enrichment in all 8 analytes studied are shown in Table S2.