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. Author manuscript; available in PMC: 2015 Mar 25.
Published in final edited form as: Mol Cell Endocrinol. 2013 Sep 19;385(0):28–35. doi: 10.1016/j.mce.2013.09.012

FIG. 1.

FIG. 1

Model for the regulation of Fshb and Lhb transcription by pulsatile GnRH. Fast and slow frequency pulsatile GnRH stimulates signaling cascades that mediate the activity and synthesis of transcription factors controlling gonadotropin subunit gene transcription. The pathways stimulated by GnRH can vary in magnitude and duration (as indicated by weighted arrows) in a manner dependent on pulse frequency and lead to the induction of distinct transcription factor networks.