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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Connect Tissue Res. 2014 Jan 10;55(2):115–122. doi: 10.3109/03008207.2013.862528

Figure 4.

Figure 4

Morphology of the collagen assemblies formed in the presence of the anti-α2Ct scFv construct added at indicated scFv:collagen I molar ratios. As indicated by the punctate staining seen in panels A and B, at the highest scFv:collagen I molar ratios, the formation of properly folded spindle-shaped collagen fibrils is inhibited. In contrast, at the relatively low concentrations of inhibitory scFv, abundant spindle-shaped collagen fibrils are formed (D, E). Panels C and F depict the ultrastructure of assemblies formed at high (C) and low (F) scFv: collagen I molar ratios. Arrows indicate fibrils with pointed and blunt ends.

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