Table 2.
Comparison of GCK gene DNA methylation levels between cases and controls in male and female separately.
| DNA methylation (%) | Male | Female | ||||
|---|---|---|---|---|---|---|
| Case | Control | P | Case | Control | P | |
| CpG1 | 50.17 ± 8.50 | 54.06 ± 7.19 | 0.321 | 49.83 ± 8.42 | 51.39 ± 9.20 | 0.674 |
| CpG2 | 42.72 ± 9.52 | 49.56 ± 7.57 | 0.030* | 44.11 ± 6.15 | 49.28 ± 9.12 | 0.067 |
| CpG3 | 57.17 ± 8.99 | 62.67 ± 8.46 | 0.155 | 56.44 ± 8.73 | 61.44 ± 10.79 | 0.138 |
| CpG4 | 48.06 ± 7.01 | 53.61 ± 7.06 | 0.085 | 49.67 ± 7.96 | 53.72 ± 7.36 | 0.228 |
| Mean | 49.53 ± 6.58 | 54.97 ± 6.98 | 0.063 | 50.01 ± 6.45 | 53.96 ± 8.44 | 0.168 |
The P values were adjusted by age, history of smoking, diabetes, and hypertension.
*P < 0.05.