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. Author manuscript; available in PMC: 2014 Mar 9.
Published in final edited form as: J Thromb Haemost. 2006 Jun;4(6):1218–1225. doi: 10.1111/j.1538-7836.2006.01901.x

Fig. 4.

Fig. 4

Plasma factor VIII (FVIII) activity in canine hemophilia A dogs treated with HDV-PEPCK/BDDcFVIII/WPRE. Each dog was administered HDV on experimental day 0. Dog A received 1 × 1012 vp kg−1 body weight and dogs B and C each received 3 × 1012 vp kg−1 body weight. Periodic blood samples were collected and percent normal FVIII activity was measured by COATEST assay (A) and FVIII antigen level was measured by enzyme-linked immunosorbent assay (B). Dotted line represents lower limit of detection.