Table 3.

Multivariate Analysis

Factor	Level	N	HR	95% CI	P-value
OS
Main effect	Auto	137	1
	NST/RIC	152	2.38	(1.79 – 3.16)	<0.001
Year of 2nd transplant	1995–2004	148	1
	2005–2008	141	0.57	(0.43 – 0.75)	<0.001
Karnofsky score	≥ 90	144	1		0.001*
	<90	118	1.96	(1.47 – 2.62)	<0.001
	Missing	27	1.85	(1.14 – 3.01)	0.013
Treatment failure
Interactional effect between main effect and Durie-Salmon Stage	DS stage I–II, Auto	40	1
	DS stage I–II, NST/RIC	54	1.33	(0.87–2.02)	0.189
	DS stage III, Auto	80	1
	DS stage III, NST/RIC	88	3.05	(2.20–4.22)	<0.001
	DS missing, Auto	17	1
	DS missing, NST/RIC	10	1.53	(0.63–3.70)	0.344
Relapse
Interactional effect between main effect and Durie-Salmon Stage	DS stage I–II, Auto	40	1
	DS stage I–II, NST/RIC	54	1.16	(0.74–1.82)	0.518
	DS stage III, Auto	80	1
	DS stage III, NST/RIC	88	2.70	(1.93–3.80)	<0.001
	DS missing, Auto	17	1
	DS missing, NST/RIC	10	1.51	(0.59–3.83)	0.388
NRM
Main effect	Auto	137	1
	NST/RIC	152	7.14	(2.70–18.91)	<0.001

^*overall p-value

Auto = autotransplant

NST/RIC = non-myeloablative stem cell transplant/reduced intensity conditioning

DS = Durie-Salmon

NRM = non-relapse mortality