. Author manuscript; available in PMC: 2014 Mar 9.

Published in final edited form as: J Biomol Screen. 2010 Jul 27;15(8):918–927. doi: 10.1177/1087057110376537

Table 2. The chemical structures, Nek2 kinase IC₅₀ values and anti-proliferative effects (GI₅₀) of the viridin-like compounds.

Compound	Structure	Nek2 inhibition (IC₅₀ μM)		Growth inhibition (GI₅₀ μM)
Compound	Structure	FlashPlate^*	Filter^*	U2OS Mean ± sem	HeLa n=1
CC004729		2.9 (3.6, 2.2)	11.9	n.d.	n.d.
CC0047311		9 ± 2.7	1.4 (1.1, 1.6)	11.0 ± 3.0	1.8
CC004733		2.5 (3.3, 1.6)	4.4 (1.0, 7.7)	10.6 ± 2.9	10.2
CC004730		8.25% inhibition at 32 μM	n.d.	50% inhibition at 100μM	n.d.
Wortmannin		14	15	23.7	15.0

mean ± sd or average of 2 determinations with individual values shown in brackets. n.d., not determined.

Table 2. The chemical structures, Nek2 kinase IC50 values and anti-proliferative effects (GI50) of the viridin-like compounds.