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. Author manuscript; available in PMC: 2014 Mar 9.
Published in final edited form as: J Biomol Screen. 2010 Jul 27;15(8):918–927. doi: 10.1177/1087057110376537

Table 3. Selectivity of viridin compounds for mitotic kinases.

IC50 values (± Standard Error, logEC50) were determined for staurosporine, wortmannin, CC004731 and CC004733 for the mitotic kinases Nek2, Nek6, Nek7, Aurora A, Plk1 and Cdkl/Cyclin B in a biochemical kinase assay. >400 μM denotes no inhibition at 400 μM inhibitor, the highest concentration used in the assay.

Kinases Staurosporine Wortmannin CC004731 CC004733
Nek2 3.7 ± 0.5 14.8 ± 0.6 0.9 ± 0.2 0.5 ± 0.4
Nek6 >400 >400 >400 34.9 ± 2.6
Nek7 >400 >400 >400 >400
Aurora A 0.04 ± 1.4 >400 2.8 ± 0.1 3.6 ± 0.1
Plk1 5.1 ± 0.4 0.6 ± 0.6 4.0 ± 6.5 4.0 ± 0.1
Cdk1 0.01 ± 0.1 >400 6.7 ± 0.2 1.4 ± 0.4