. Author manuscript; available in PMC: 2014 Mar 9.

Published in final edited form as: Nat Rev Immunol. 2011 Oct 10;11(11):762–774. doi: 10.1038/nri3070

Table 1.

Mouse and human monocyte subsets

Subset	Markers	Chemokine receptors	Functions
*Mouse*
LY6C^hi	CD11b⁺CD115⁺LY6C^hi	CCR2^hiCX₃CR1^low	Pro-inflammatory⁷ and antimicrobial³ roles
LY6C^low	CD11b⁺CD115⁺LY6C^low	CX₃CR1^hiCCR2^low	Patrolling¹¹; early responses¹¹; tissue repair¹²⁸
*Human*
Classical	CD14⁺⁺CD16⁻	CCR2^hiCX₃CR1^low	Resemble LY6C^hi monocytes based on gene-expression arrays^7,17,140
Intermediate	CD14⁺⁺CD16⁺	CX₃CR1^hiCCR2^low	Pro-inflammatory roles^12,15
Non-classical	CD14⁺CD16⁺⁺	CX₃CR1^hiCCR2^low	Patrolling¹⁴; antiviral roles¹⁴

CCR2, CC-chemokine receptor 2; CX₃CR1, CX₃C-chemokine receptor 1.