Figure 2.

Selected examples of dose-response curves representing different types of variation in dose-response relationships. Patterns of dose-response across the breast cell line panel for (a) docetaxel, a microtubule stabilizer, (b) geldanamycin, an HSP90 inhibitor, (c) fascaplysin, a CDK4 inhibitor, (d) CGC-11144, a polyamine analogue, and (e) GSK2126458, a PI3K inhibitor are shown. These drugs are highlighted in red in Fig. 1c. The range of IC₅₀ and E_max values is represented by box and whisker plots drawn and median parameter values and inter-quartile ranges shown above and to the right; bars extending to 1.5-times the inter-quartile range are shown for each drug as a measure of variance. Parameter values for outlier cell lines are denoted by stars.