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. Author manuscript; available in PMC: 2014 Mar 9.
Published in final edited form as: Org Lett. 2010 Feb 19;12(4):892–895. doi: 10.1021/ol902969j

Table 1.

Catalyst and Alcohol Screening

graphic file with name nihms557339u2.jpg
entry catalyst (mol %) time, d R2 % convna % ee
1 11 (5) 1 Me 54 <3
2 11 (5) 1 PhCH2 47 −25
3 11 (5) 1 Ph2CH 5 ND
4 11 (10) 1 1-Np2CH <5 ND
5 10 (5) 2 Me 91b 34b
6 10 (5) 2 PhCH2 94b 48b
7 10 (5) 2 1-NpCH2 97b 51b
8 10 (5) 2 2-NpCH2 96b 47b
9 10 (5) 2 Me2CH <5 ND
10 10 (5) 2 Ph2CH 91b 75b
11 10 (5) 2 1-Np2CH 96b 85b
12 10 (10) 0.4 1-Np2CH 92b 80b
13 8 (10) 2 1-Np2CH 47 59
14 9 (10) 2 1-Np2CH 47 −52
a

Conversion was determined by 1H NMR, unless indicated otherwise.

b

Reported % isolated yields and % ee’s are averages of two runs.