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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Curr Opin Virol. 2013 Apr 16;3(3):251–259. doi: 10.1016/j.coviro.2013.03.004

Figure 1. Progressive Epigenetic Modifications Regulate Gammaherpesvirus Latency.

Figure 1

Early stage histone modifications lead to metastable gene expression programs, which are reinforced by secondary higher-order chromosome conformations, including DNA looping. DNA methylation occurs more gradually and may take the place of repressive histone modifications to increase epigenetic stability.