Skip to main content
. Author manuscript; available in PMC: 2015 Jan 31.
Published in final edited form as: Neuroscience. 2013 Nov 14;258:111–120. doi: 10.1016/j.neuroscience.2013.11.008

Figure 3.

Figure 3

Leptin produces nociceptor sensitization. (A) Thirty min. after injection, rrleptin significantly increased the number of spikes in recordings obtained during the early part of the stimulation period (first 10 s, n = 20, P < 0.01), as well as total response (60 s, n = 20, P < 0.05), compared to pre-rrleptin injection values. One hour after injection, rrleptin not only increased the number of spikes in recordings obtained during the early part of the stimulation period (first 10 s, n = 20, P < 0.01), but also in its late component (last 50 s, n = 20, P < 0.05) and total response (60 s, n = 20, P < 0.05) compared to pre-injection values. This increased response at 1 h. after rrleptin injection was also evident in histograms depicting the time-course of the nociceptor response, representing recordings obtained pre and post rrleptin injection (B-D); *P < 0.05; **P < 0.01.