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Leptin-induced hyperalgesia is estrogen-dependent. Ovariectomized rats were treated with either 17β-estradiol or vehicle for 3 consecutive days. One day after, they received an i.m. injection of rrleptin (1 μg/20 μl) and muscle mechanical nociceptive threshold was measured 1 or 24 h after rrleptin injection. Rats without estrogen replacement exhibited a marked attenuation of the nociceptive response induced by rrleptin; ** P < 0.001.
