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. Author manuscript; available in PMC: 2015 Jan 31.
Published in final edited form as: Neuroscience. 2013 Nov 14;258:111–120. doi: 10.1016/j.neuroscience.2013.11.008

Figure 5.

Figure 5

Intralesional leptin receptor antagonist inhibits mechanical hyperalgesia in rats submitted to a model of endometriosis pain. Two weeks after surgical implant of autologous uterine tissue, rats displayed a marked mechanical hyperalgesia (EMS, endometriosis pain model). (A) Single intralesional injection of leptin receptor pegylated antagonist (3 μg/20 μl), but not vehicle (Veh), produced an attenuation of mechanical hyperalgesia at 1 h after injection which reached a maximal effect 24 h. after injection; (B) Repeated intralesional injections of leptin receptor pegylated antagonist (3 μg/20 μl*3) produced an inhibition of mechanical hyperalgesia lasting at least 3 days after last injection. (C) Administration of leptin receptor pegylated antagonist (3 μg/20 μl) into the contralateral gastrocnemius muscle was devoid of effect. *P < 0.05; ***P < 0.001.