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Inhibition of leptin receptor signalling attenuates mechanical hyperalgesia in rats submitted to a model of endometriosis pain. Two weeks after surgical implant of autologous uterine tissue, rats displayed a marked mechanical hyperalgesia (EMS, endometriosis pain model). In these rats, a single local injection of the selective inhibitor of JAK2 (AG490), but not vehicle (Veh), produced an attenuation of mechanical hyperalgesia between 1 to 24 h. after injection; ***P < 0.001.
