Figure 3. Detection of intraepithelial eosinophils, mast cells and collegen in IL-13 gene-deficient mice following Aspergillus-induced EoE.
The EoE characteristics features were examined in wild type and IL-13 gene-deficient mice following the induction of Aspergillus antigen-induced experimental EoE. Both wild type and IL-13 gene-deficient mice show intraepithelial eosinophils (A, B, original magnification 200×), mast cells (C, D, original magnification 200×) and lamina propria and epithelial mucos collegen accumulation (E, F, original magnification 400×). Arrows indicates intraepithelial eosinophils or lamina propria mast cells in the respective phomicrographs. The quantitation of collagen thickness and mast cells numbers in wild type and IL-13 gen-deficient mice are shown (G, H). The results are expressed as mean ± S.D. (n = 8 mice/group). EP-Epithelium, LP-Lamina propria, LU-Lumen, MM-Muscular Mucosa,