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. Author manuscript; available in PMC: 2014 Mar 9.
Published in final edited form as: Sci Signal. 2013 Aug 6;6(287):ra66. doi: 10.1126/scisignal.2004155

Fig. 5. AXL signaling is required for EGF-elicited protrusion.

Fig. 5

(A) Mean loadings of the reduced partial least-squares regression models. The red point corresponds to the projection of the phenotype. Error bars indicate the SE for the family of reduced models. (B) Protrusion predictions from reduced partial least-squares regression models for wild-type (by cross-validation) and AXL knockdown (by prediction) cells. Error bars indicate the SE of prediction across the family of reduced models. (C) EGF-elicited protrusion response of MDA-MB-231 cells upon AXL knockdown (***P < 0.001, Mann-Whitney test; n = 13 to 25 from three independent experiments). (D) EGF-elicited protrusion responses with or without 0.3 µM R428 (***P < 0.001, Mann-Whitney test; n = 17 to 35 from three independent experiments). MDA-MB-231 and MDA-MB-157 cells express AXL, whereas MCF7 and T47D cells do not.