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. Author manuscript; available in PMC: 2014 Mar 12.
Published in final edited form as: Curr Gene Ther. 2013 Apr;13(2):93–98. doi: 10.2174/1566523211313020003

Figure 1. Causes of genome alterations in iPSCs.

Figure 1

Genome alterations in iPSCs can be the consequence of: (A) variations or mutations that are present at high or low frequency in the parental cells; clonal selection during iPSC generation can select and/or fix these variants; (B) insertional mutagenesis, replicative stress, caused for example by forced expression of an oncogene, can result in DNA damage that might not be properly repaired; (C) iPSCs could be intrinsically genetically unstable, and sub-optimal culture conditions might favor the generation and/or the selection of clones that are fitter for in vitro culture conditions.