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. 2014 Jan 10;122(3):284–291. doi: 10.1289/ehp.1307429

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(A) Arsenic exposure perturbed the metabolic profile of fecal samples of mice, with 370 molecular features being significantly changed compared with controls (fold change > 1.5 and p < 0.05). (B) Controls were separated from arsenic-treated mice in metabolite profiles by PCA. (C) Hierarchical clustering heat map constructed using molecular features with 1.5-fold changes (p < 0.05) shows a consistent clustering pattern within individual groups.