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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Genes Immun. 2013 Nov 28;15(2):63–71. doi: 10.1038/gene.2013.60

Table 2. Association of TLR5 variants with blood cytokine response to flagellin.

Variant Minor allele
frequency		 IL-6 Cytokine IL-1ra
P values1
Dominant Recessive Additive Dominant Recessive Additive
rs2072493 0.26 0.202 0.72 0.246 0.468 0.957 0.579
rs2096142 0.23 0.027 0.039 0.010 0.261 0.002 0.032
rs2241096 0.25 0.127 0.139 0.070 0.043 0.128 0.027
rs2241097 0.04 0.324 0.259 0.245 0.051 0.745 0.058
rs2353476 0.23 0.027 0.039 0.010 0.261 0.002 0.032
rs5744113 0.23 0.023 0.058 0.011 0.253 0.005 0.042
rs17163737 0.21 0.017 0.619 0.051 0.050 0.509 0.052
1

P values determined by linear regression of association of each variant with log transformed cytokine level induced by stimulation of whole blood from 300 healthy subjects with 500 ng/mL flagellin.