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. 2014 Jan 8;34(3):542–551. doi: 10.1038/jcbfm.2013.233

Figure 3.

Figure 3

Effects of treatment with the peroxisome proliferator-activated receptor-α (PPAR-α) agonist fenofibrate on postischemic inflammation in rats. (A) Neutrophil infiltration was decreased after the induction of ischemia by fenofibrate treatment (n=4 per group); *P<0.05 vs. IR+Veh group. Scale bar, 100 μm. (B) Immunohistochemical quantification of the expression of Ox-42 revealed a significant decrease after fenofibrate treatment (n=4 per group); *P<0.05 vs. IR+Veh group. Scale bar, 25 μm. (C) Quantitative evaluation of the intercellular adhesion molecule-1 (ICAM-1) (using immunohistochemistry and western blotting) revealed a significant decrease in the expression of this protein during fenofibrate treatment (n=4 per group) after the induction of ischemia; *P<0.05 vs. Sham group; #P<0.05 vs. IR+Veh group. Scale bar, 100 μm. IR, ischemia/reperfusion.