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. 2014 Jan 8;34(3):542–551. doi: 10.1038/jcbfm.2013.233

Figure 4.

Figure 4

Effects of delayed treatment with the peroxisome proliferator-activated receptor-α (PPAR-α) agonist fenofibrate on infarct volume, motor level, neurologic deficit, and memory recovery. (A) Delayed administration of fenofibrate enabled a reduction in infarct size. *P<0.05 vs. IR+Veh group. (B) Delayed and prolonged administration of fenofibrate induced motor improvements in grip strength test. *P<0.05 vs. Sham+Veh group; #P<0.05 vs. IR+Veh group. (C) Fenofibrate prevented neurologic deficits induced by ischemia. *P<0.05 vs. IR+Veh group. (D) The postischemia visuo-spatial memory impairment (as evaluated in Y-maze test) was prevented in fenofibrate-treated rats (n=16) than in ischemic animals (n=20). *P<0.05 vs. Sham group; #P<0.05 vs. IR+Veh group. IR, ischemia/reperfusion.