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. 2014 Jan 8;34(3):542–551. doi: 10.1038/jcbfm.2013.233

Figure 6.

Figure 6

Effects of treatment with the peroxisome proliferator-activated receptor-α (PPAR-α) agonist fenofibrate during the acute phase of cerebral ischemia on stroke-induced amyloid deposition and amyloid-related secretases. (A) Amyloid-β peptide deposition around the boundary of the ischemic focus was decreased 7 days after the induction of ischemia by fenofibrate treatment in the rat (n=4 per group); *P<0.05 vs. IR+Veh group. Scale bar, 25 μm. (B) Analysis of A Disintegrin And Metalloproteinase-10 (ADAM-10), BACE-1, PS-1, PS-2, and APP mRNA levels in whole brain lysates from the striatum or the hippocampus regions showed that ischemia/reperfusion induced a decrease in ADAM-10 and PS-1 mRNA level; *P<0.05 vs. Sham+Veh group. Nevertheless, fenofibrate administration did not significantly downregulate ADAM-10 and PS-1 mRNA while ADAM-10 inhibition was less important in fenofibrate-treated group. IR, ischemia/reperfusion.