Table 5.
Logistic regression analyses of different GAS6 SNP on abnormal variables among adolescents.
| Variablesb | GAS6 rs8191973 | GAS6 rs8191974 | ||
|---|---|---|---|---|
| GG OR (95% CI)a | GG OR (95% CI)a | |||
| Unadjusted | Adjustedc | Unadjusted | Adjustedc | |
| Boys | ||||
| High BMI | 1.12 (0.47–2.68) | 1.26 (0.34–4.76) | 1.40 (1.06–2.99)d | 1.85 (1.04–3.23)d |
| High WC | 0.82 (0.38–1.76) | 1.11 (0.39–5.26) | 1.58 (1.18–2.01)d | 1.68 (1.08–3.25)d |
| High hsCRP | 1.87 (1.25–2.87)d | 2.53 (1.03–6.24)d | 1.88 (0.68–3.25) | 1.92 (0.93–3.96) |
| High TNF-α | 4.26 (0.99–18.37) | 3.34 (0.42–24.98) | 0.93 (0.43–1.98) | 0.99 (0.33–2.94) |
| High IL-6 | 2.09 (0.92–4.82) | 2.27 (0.98–5.26) | 2.68 (1.32–5.20)d | 2.56 (1.33–5.00)d |
| High HOMA-IR | 1.41 (0.56–3.52) | 1.14 (0.31–4.17) | 1.28 (0.61–2.67) | 2.35 (0.73–7.69) |
| Girls | ||||
| High BMI | 0.76 (0.36–1.61) | 0.57 (0.22–1.45) | 1.09 (0.53–2.26) | 1.10 (0.43–2.86) |
| High WC | 0.60 (0.30–1.23) | 0.44 (0.17–1.11) | 1.26 (0.60–2.64) | 1.57 (0.55–4.55) |
| High hsCRP | 0.90 (0.41–1.96) | 1.04 (0.39–2.78) | 1.19 (0.58–2.44) | 1.05 (0.44–2.50) |
| High TNF-α | 0.91 (0.41–2.04) | 0.69 (0.24–1.96) | 1.00 (0.47–2.13) | 0.85 (0.31–2.33) |
| High IL-6 | 1.37 (0.61–3.09) | 0.90 (0.34–2.50) | 1.42 (0.69–2.95) | 1.68 (0.06–4.55) |
| High HOMA-IR | 0.76 (0.33–1.72) | 0.69 (0.25–1.92) | 1.48 (0.64–3.41) | 2.20 (0.70–7.14) |
aUnder a recessive model (using heterozygotes and minor homozygotes as the reference for each SNP). bAbnormal variables were determined using an age- and gender-specific 90th percentile cut-off point.
cAdjusting for age, Tanner stage, cigarette smoking, alcohol drinking, and physical activity.
d P < 0.05.
OR: odds ratio; CI: confidence index; BMI: body mass index; WC: waist circumference; HOMA-IR: homeostasis model assessment of insulin resistance; hsCRP: high-sensitivity C-reactive protein; TNF-α: tumor necrosis factor-α; IL-6: interleukin-6.