Fig. 1.

Animal experimental schematics (A) and general behavior characterization (B-G). B, Survival rate 42 days after icv STZ injection. C, The body weights of the mice after icv injection were monitored once a week. D, Motor coordination and balance were evaluated using accelerating Rotarod. E-F, Spontaneous locomotor and exploratory activity was assessed in an open field, and the time spent in the central area (E) and the total distance traveled in the open field (F) are shown. G, Anxiety-like behavior was assessed in the elevated plus maze by measuring the percentage of time spent on open arms. *p < 0.05 vs. WT-saline; ^#p < 0.05 vs. 3xTg-saline.