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Effects of icv STZ on the brain insulin signaling pathway in 3xTg-AD mice. (A) Hippocampal homogenates from WT-saline, 3xTg-saline and 3xTg-STZ mice were analyzed by Western blots developed with antibodies indicated on the left of the blots. (B, C) Densitometrical quantification of the blots after normalization with either the GAPDH level (B) or the corresponding protein level (C). *p < 0.05 vs. WT-saline; #p < 0.05 vs. 3xTg-saline.
