. Author manuscript; available in PMC: 2015 Feb 1.

Published in final edited form as: Mol Neurobiol. 2013 Aug 30;49(1):601–614. doi: 10.1007/s12035-013-8541-4

Table 2.

Targeted Enrichment/Amplicon Resequencing Platform Comparison

Application	Size	Agilent	Lifetech	Illumina	RainDance
Target size (sequencing platform)	1–10 kb	HaloPlex (ILM, ION)	Ion Xpress (ION)	TruSeq (MSE, HSE)	RDT 1000 (ILM, ION, SOL, ROC)
	10–500 kb	HaloPlex (ILM, ION)	TargetSeq (ION, SOL)
	200 kb-10 Mb	SureSelect (ILM, SOL, ROC)	TargetSeq (ION, SOL)
Enrichment		Probe (< 10 Mb)	Amplicon (<10 kb) Probe (0.1–10 Mb)	Amplicon (<500 kb) Probe (0.5–25 Mb)	Amplicon (< 10 Mb)
Application		Compatible with most high-throughput sequencing platforms; widely adopted	Work only with Ion Torrent or SOLiD system	Work only with MSE or HSE system	Many panels available: cancer, ASD, HLA, pharmacogenetic, etc.
Cost		$$	$	$	$$$

Abbreviations: ILM = ILLUMINA, SOL = SOLiD, ION = Ion Torrent, ROC = ROCHE, MSE = Illumina MiSeq, HSE = Illumina HiSeq.