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. 2014 Feb 18;111(9):E856–E865. doi: 10.1073/pnas.1316447111

Fig. 8.

Fig. 8.

SLAYGLR Opn fragment is proinflammatory. (A) Representative photographs of colonic sections and histological scores of BALB/c Spp1−/− recipients of Spp1−/− CD103− DCs pretreated with scrambled frOpn (frOpnscr) (1), frOpnRGD (2), and frOpnRAA (3). (Magnification: 10×.) (Scale bars: 200 μm.) MLN DC ratios (B) and numbers of IL-17A+, IFN-γ+ (C) and IL-10+, Foxp3+ (D) MLN CD4+ T cells per mouse are shown. (E) Il23p19 mRNA expression by Spp1−/− CD103− DCs treated with RPMI or Opn fragments. Values are expressed as mean ± SEM (n = 6 mice per group) from three separate experiments (*P < 0.05; **P < 0.01; ***P < 0.001).