Fig. 1.
Clustering analysis of metabolic gene expression profiles for cancer and tumor-adjacent normal samples. (A) Hierarchical clustering of absolute metabolic gene expression levels (RPKM) for cancer and tumor-adjacent normal samples, featuring only those genes that significantly changed expression across most cancer types upon transformation, thereby subtracting the effect of the tissue of origin. (Lower) Corresponding tissue of origin for each sample in the heatmap above. (B) PCA of log2 metabolic gene expression fold-change vs. matched tumor-adjacent normal samples for ccRCC (gray) and other cancer type samples (orange).