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. 2014 Feb 18;111(9):E866–E875. doi: 10.1073/pnas.1319196111

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Fig. 4. — Reconstruction and comparison of ccRCC-specific GEM (iRenalCancer1410) against other cancer-type GEMs and the normal kidney cell in tubules GEM. (A) Venn diagram for the metabolic genes present in iRenalCancer1410 compared with other reconstructed GEMs (cancers, Left, kidney cell in tubules, Right). Metabolic genes absent in iRenalCancer1410 but present both in the kidney cell in tubules GEM and other cancer type GEMs were used to enrich canonical pathways. (B) Nucleotide metabolism featuring the staining level of proteins taken from HPA for different tissues (Center: ccRCC; Left: BR, breast cancer; BL, bladder cancer; LI, liver cancer; LU, lung cancer; Right: NK, kidney cell in tubules).