Table 2.
Microsomal stability screen data summary.
Compound | Concentration (µM) |
Mean remaining | Comments | |
---|---|---|---|---|
Parent comp (%) | Parent comp (%) | |||
(+)NADPH | (−)NADPH | |||
Verapamil | 1 | 5.6 | 113 | High metabolized control |
Warfarin | 1 | 83.9 | 118 | Low metabolized control |
1 | 1 | 5.1 | 112 | |
4 | 1 | 90.2 | 115 | |
8 | 1 | 91.6 | 120 | |
10 | 1 | 1.0 | 108 |