Table 1. Baseline Characteristics of 96 Hospitalized New TB Patients by HIV status in Kampala, Uganda.
Factor | Level | HIV uninfected (n = 32) | HIV infected (n = 64) |
– n (%) (unless specified) – | |||
Age (years) | Mean (SD) | 32.3 (13.8) | 33.1 (8.2) |
Sex | Female | 7 (22%) | 39 (61%) |
Male | 25 (78%) | 25 (39%) | |
BMI (kg/m2) | Mean (SD) | 16.6 (3.1) | 17.5 (3.5) |
Karnofsky score | 70+ | 20 (62.5%) | 36 (56%) |
≤60 | 12 (37.5%) | 28 (44%) | |
Duration of TB symptoms (weeks) | Median (IQR) | 16 (8 – 24) | 12 (8 – 16) |
Drug resistance status at baseline | Sensitive to INH and RIF | 29 (91%) | 60 (94%) |
Resistance to INH or RIF | 2 (6%) | 4 (6%) | |
MDR | 1 (3%) | 0 | |
Extent of disease on chest radiograph | Normal | 0 | 7 (11%) |
Minimal | 0 | 14 (22%) | |
Moderate | 3 (10%) | 15 (24%) | |
Severe | 28 (90%) | 27 (43%) | |
Cavitation | Absent | 4 (13%) | 49 (80%) |
Present | 27 (87%) | 12 (20%) | |
Miliary infiltrate | Absent | 30 (97%) | 58 (92%) |
Present | 1 (3%) | 5 (8%) | |
Sputum AFB smear microscopy grade | 1+ | 3 (9%) | 4 (6%) |
2+ | 3 (9%) | 14 (22%) | |
3+ | 5 (16%) | 11 (17%) | |
4+ | 21 (66%) | 35 (55%) | |
BACTEC days-to-positive culture | ≥7 days | 14 (44%) | 32 (50%) |
<7 days | 18 (56%) | 32 (50%) | |
CD4 cell count (cells/µL) | Median (IQR) | - | 58 (18 – 106) |
Symptoms (multiple responses allowed) | Fever | 20 (62%) | 51 (80%) |
Rigors | 9 (28%) | 7 (11%) | |
Night sweats | 21 (66%) | 46 (72%) | |
Cough | 32 (100%) | 63 (98%) | |
Produce sputum | 32 (100%) | 62 (97%) | |
Purulent sputum | 18 (56%) | 29 (45%) | |
Hemoptysis | 5 (16%) | 2 (3%) | |
Dyspnea | 21 (66%) | 52 (81%) | |
Chest Pain | 22 (69%) | 46 (72%) | |
Loss of appetite | 21 (66%) | 53 (83%) | |
Diarrhoea | 2 (6%) | 3 (5%) | |
Weight Loss | 26 (81%) | 60 (94%) | |
Swollen Glands | 0 | 12 (19%) | |
Malaise | 23 (72%) | 52 (81%) | |
Reason for hospitalization | Low Karnofsky score | 15 (47%) | 46 (72%) |
Diagnostic evaluation | 8 (25%) | 9 (14%) | |
Concurrent Illness | 2 (6%) | 10 (16%) | |
Haemoptysis | 3 (9%) | 0 | |
Social support | 2 (6%) | 0 | |
Drug side effects | 0 | 0 | |
Two reasons for admission | 3 (9%) | 2 (3%) | |
Other reasons | 5 (16%) | 1 (2%) |