Figure 7.
The rate of change in participants with low risk of Alzheimer's disease. From the ADNI sample, subgroups of participants with very low risk of Alzheimer's disease (AD) were selected based on 2-year clinical and neuropsychological stability (n = 18), levels of CSF Aβ1-42 (n = 28) or a combination of CSF Aβ1-42 levels and no APOE ɛ4 alleles (n = 22). The annual rate of change in the entorhinal cortex did not differ statistically between any of the subgroups and the full ADNI sample. Thus, it is very unlikely that thinning in this area in healthy older adults is solely caused by undetected AD processes.