Table 4.
Effects of inclusion of mild Alzheimer's disease (AD) on estimated lifespan trajectories
| Without Alzheimer patients |
With Alzheimer patients |
||||
|---|---|---|---|---|---|
| Linear BIC | Smoothing spline ΔBIC | Smoothing spline ΔBIC | Linear BIC | Direction of change with age | |
| Lateral orbitofrontal | 524.01 | 21.90 | 15.82 | 788.48 | Decelerating |
| Rostral anterior cingulate | 845.08 | 20.74 | 24.02 | 1212.82 | Decelerating |
| Medial orbitofrontal | 667.35 | 14.47 | 9.68 | 969.18 | Decelerating |
| Pars orbitalis | 676.34 | 8.46 | 7.17 | 1033.09 | Decelerating |
| Lateral occipital | 387.5 | 8.24 | 11.22 | 657.66 | Accelerating |
| Middle temporal | 502.28 | 5.15 | 2.35 | 837.54 | Decelerating |
| Pars triangularis | 443.31 | 3.65 | 4.21 | 739.8 | Decelerating |
| Rostral middle frontal | 646.68 | 1.82 | 1.82 | 646.68 | |
| Superior frontal | 717.9 | 1.63 | 1.63 | 717.9 | |
| Lingual | 574.55 | 1.57 | 1.57 | 574.55 | |
| Pars opercularis | 712.33 | 1.42 | 1.42 | 712.33 | |
| Inferior temporal | 860.68 | 1.33 | 1.33 | 860.68 | |
| Caudal middle frontal | 733.76 | 0.04 | 0.04 | 733.76 | |
| Caudal anterior cingulate | 753.77 | 0.02 | 0.00 | 1139.82 | |
| Entorhinal | 1045.87 | 0.00 | 3.30 | 1559.54 | Accelerating |
| Posterior cingulate | 624.96 | 0.00 | 0.00 | 624.96 | |
| Superior parietal | 753 | 0.00 | 0.00 | 753 | |
| Superior temporal | 826.81 | 0.00 | 0.00 | 826.81 | |
| Frontal pole | 1167.49 | 0.00 | 0.00 | 1167.49 | |
| Banks sup temp sulc | 824.43 | −0.01 | −0.01 | 824.43 | |
| Fusiform | 778.03 | −0.01 | −0.01 | 778.03 | |
| Retrosplenial | 956.25 | −0.01 | −0.01 | 956.25 | |
| Supramarginal | 704.43 | −0.01 | −0.01 | 704.43 | |
| Cuneus | 690.36 | −0.02 | −0.02 | 690.36 | |
| Inferior parietal | 697.65 | −0.02 | −0.02 | 697.65 | |
| Parahippocampal | 1338.99 | −0.02 | −0.02 | 1338.99 | |
| Paracentral | 792.62 | −0.02 | −0.02 | 792.62 | |
| Pericalcarine | 614.01 | −0.02 | −0.02 | 614.01 | |
| Postcentral | 614.01 | −0.02 | −0.02 | 614.01 | |
| Precentral | 726.57 | −0.02 | −0.02 | 726.57 | |
| Precuneus | 728.51 | −0.02 | −0.02 | 728.51 | |
| Temporal pole | 1453.43 | −0.02 | −0.02 | 1453.43 | |
| Transverse temporal | 1074.21 | −0.02 | −0.02 | 1074.21 | |
Note: The column “smoothing spline ΔBIC” denotes the change in BIC between the linear and the smoothing spline model, and the ROIs are sorted according to this value. ΔBIC ≥4 indicates that a nonlinear model is considerably better than a linear model, whereas ΔBIC ≤2 indicates that the best model is essentially indistinguishable from a linear model. In the columns “Without Alzheimer patients,” only the healthy controls are included (n = 309). In the columns “With Alzheimer patients,” a group of mild AD patients (n = 96) was added to the sample, and the analyses rerun. For entorhinal cortex, a low ΔBIC in the group without AD and a higher ΔBIC in the group with AD indicate that inclusion of AD patients had a substantial effect on the estimated lifespan trajectory of this region.