Table 3.
Effect of FH of AD on CBF
| Contrast | Anatomical label | Voxels | Peak T-value | MNI x, y, z coordinates |
|---|---|---|---|---|
| FH− > FH+ | Right superior frontal gyrus | 123 | 3.55 | 12, −6, 76 |
| Right superior frontal gyrus | 210 | 2.95 | 32, 54, 32 | |
| FH− > mFH+ | Right superior frontal gyrus | 4161 | 4.18 | 12, −6, 76 |
| Left medial superior frontal gyrus | 109 | 3.58 | −10, 36, 62 | |
| Right hippocampus | 646 | 3.40 | 24, −10, −12 | |
| Left superior frontal gyrus | 139 | 3.35 | −10, −4, 80 | |
| Right supramarginal gyrus | 538 | 3.29 | 54, −34, 24 | |
| Left hippocampus | 181 | 3.25 | −28, −12, −12 | |
| Left middle frontal gyrus | 140 | 3.16 | −48, 28, 42 | |
| FH− > pFH+ | X | X | X | X |
| FH− > mpFH+ | X | X | X | X |
| mFH+ < pFH+ | Left superior frontal gyrus | 270 | 3.52 | −12, 26, 42 |
| Left hippocampus | 960 | 3.40 | −34, −22, −16 | |
| Right middle frontal gyrus | 207 | 3.33 | 28, 28, 30 | |
| Right supramarginal gyrus | 151 | 3.25 | 52, −48, 30 | |
| Right medial superior frontal gyrus | 440 | 3.21 | 12, 50, 18 | |
| Left supramarginal gyrus | 118 | 3.12 | −56, −42, 30 | |
| Right superior frontal gyrus | 101 | 2.79 | 14, 40, 36 | |
| mFH+ < mpFH+ | X | X | X | X |
AD = Alzheimer's disease; CBF = cerebral blood flow; MNI = Montreal Neurological Institute; FH− = negative family history of AD; FH+ = positive family history of AD; mFH+ = maternal family history of AD; pFH+ = paternal family history of AD; mpFH+ = history of AD in both parents; X = no significant group differences.