. 2013 Jan 14;15(9):674–680. doi: 10.1111/hpb.12019

Table 2.

Impact of demographic, surgical and histopathological variables on survival

Variables		Overall survival			Disease-free survival
		Median OS (IQR) – mths	Univariate P-value	Multivariate P-value	Median OS (IQR) – months	Univariate P-value	Multivariate P-value
Gender			0.618			0.819
Vascular resection			0.674			0.678
Type of reconstruction			0.754			0.844
Tumour size			0.13			0.955
Differentiation (Binomial Variable)	Well/Mod	18.57 (16.65)	0.031	0.161	7.42 (6.37)	0.06	0.30
Differentiation (Binomial Variable)	Poorly	13.53 (19.68)	0.031	0.161	6.08 (6.08)	0.06	0.30
Neural invasion			0.973			0.631
Lymphovascular invasion	−ve	24.26 (26.56)	0.013	0.631	8.3 (13.1)	0.022	0.155
Lymphovascular invasion	+ve	16.37 (15.65)	0.013	0.631	7.42 (7.0)	0.022	0.155
SMV/PV groove invasion	−ve	19.57 (27.98)	0.065	0.167		0.363
SMV/PV groove invasion	+ve	14.47 (18.84)	0.065	0.167		0.363
Resection status (R0/R1)	−ve	22.43 (28.53)	0.015	0.840		0.301
Resection status (R0/R1)	+ve	16.30 (18.48)	0.015	0.840		0.301
Ant. margin status			0.275			0.838
Post. margin status	−ve	18.57 (22.58)	0.062	0.652		0.012	0.292
Post. margin status	+ve	16.30 (17.78)	0.062	0.652		0.012	0.292
CBD margin			0.762			0.507
+ve lymph node status	−ve	26.13 (32.26)	0.005	0.048	10.34 (17.52)	0.016	0.075
+ve lymph node status	+ve	16.30 (16.27)	0.005	0.048	7.10 (6.80)	0.016	0.075
Lymph node ratio (LNR)^*			0.018	0.016		0.287
Lymph node burden (LNB)^*			0.0005	0.0029		0.207
Total nodes^*			0.034	0.106		0.444

CBD, common bile duct; LNR, lymph node ratio; LNB, lymph node burden.