Table 1.
List of the solute carrier (SLC) families in zebrafish (Danio rerio) compared to human
| Zebrafish |
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|---|---|---|---|---|---|---|---|
| Human |
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| Family | Name | Total genes | Total genes | Non-duplicated genes | Duplicated genes designated as ‘a’ and ‘b’ | Duplicated genes designated as ‘tandem duplicate’ | Possibly duplicated genes and/or genes not obviously designated |
| SLC1 | High affinity glutamate and neutral amino acid transporter family | 7 | 9 | 5 | 4 | 0 | 0 |
| SLC2 | Facilitative GLUT transporter family | 14 | 12 | 6 | 2 | 0 | 4 |
| SLC3 | Heavy subunits of the heteromeric amino acid transporters | 2 | 2 | 1 | 1 | 0 | 0 |
| SLC4 | Bicarbonate transporter family | 10 | 6 | 3 | 3 | 0 | 0 |
| SLC5 | Sodium glucose cotransporter family | 12 | 8 | 7 | 0 | 0 | 1 |
| SLC6 | Sodium-and chloride-dependent neurotransmitter transporter family | 20 | 13 | 8 | 4 | 0 | 1 |
| SLC7 | Cationic amino acid transporter/ glycoprotein-associated family | 14 | 10 | 6 | 0 | 0 | 4 |
| SLC8 | Na+–Ca2+ exchanger family | 4 | 4 | 1 | 3 | 0 | 0 |
| SLC9 | Na+–H+ exchanger family | 13 | 7 | 5 | 1 | 1 | 0 |
| SLC10 | Sodium bile salt cotransport family | 7 | 4 | 4 | 0 | 0 | 0 |
| SLC11 | Proton-coupled metal ion transporter family | 2 | 1 | 1 | 0 | 0 | 0 |
| SLC12 | Electroneutral cation-coupled Cl cotransporter family | 9 | 8 | 5 | 1 | 1 | 1 |
| SLC13 | Human Na+-sulfate–carboxylate cotransporter family | 5 | 4 | 3 | 0 | 0 | 1 |
| SLC14 | Urea transporter family | 8 | 1 | 1 | 0 | 0 | 0 |
| SLC15 | Proton oligopeptide cotransporter family | 4 | 3 | 2 | 1 | 0 | 0 |
| SLC16 | Monocarboxylate transporter family | 14 | 10 | 7 | 2 | 0 | 1 |
| SLC17 | Vesicular glutamate transporter family | 9 | 5 | 3 | 2 | 0 | 0 |
| SLC18 | Vesicular amine transporter family | 4 | 3 | 2 | 1 | 0 | 0 |
| SLC19 | Folate/thiamine transporter family | 3 | 3 | 2 | 0 | 0 | 1 |
| SLC20 | Type III Na+-phosphate cotransporter family | 2 | 2 | 1 | 1 | 0 | 0 |
| SLC21 | Organic anion transporting family | 11 | 11 | 11 | 0 | 0 | 0 |
| SLC22 | Organic cation/anion/zwitterion transporter family | 23 | 5 | 4 | 1 | 0 | 0 |
| SLC23 | Na+-dependent ascorbic acid transporter family | 4 | 2 | 2 | 0 | 0 | 0 |
| SLC24 | Na+/(Ca2+–K+) exchanger family | 5 | 4 | 3 | 1 | 0 | 0 |
| SLC25 | Mitochondrial carrier family | 53 | 35 | 26 | 8 | 0 | 1 |
| SLC26 | Multifunctional anion exchanger family | 11 | 8 | 7 | 0 | 0 | 1 |
| SLC27 | Fatty acid transport protein family | 6 | 4 | 2 | 2 | 0 | 0 |
| SLC28 | Na+-coupled nucleoside transport family | 3 | 0 | 0 | 0 | 0 | 0 |
| SLC29 | Facilitative nucleoside transporter family | 4 | 3 | 2 | 0 | 0 | 1 |
| SLC30 | Zinc efflux family | 10 | 9 | 8 | 1 | 0 | 0 |
| SLC31 | Copper transporter family | 2 | 2 | 2 | 0 | 0 | 0 |
| SLC32 | Vesicular inhibitory amino acid transporter family | 1 | 1 | 1 | 0 | 0 | 0 |
| SLC33 | Acetyl-CoA transporter family | 1 | 1 | 1 | 0 | 0 | 0 |
| SLC34 | Type II Na+-phosphate cotransporter family | 3 | 2 | 0 | 1 | 0 | 1 |
| SLC35 | Nucleoside-sugar transporter family | 30 | 19 | 16 | 3 | 0 | 0 |
| SLC36 | Proton-coupled amino acid transporter family | 4 | 1 | 1 | 0 | 0 | 0 |
| SLC37 | Sugar-phosphate/phosphate exchanger family | 4 | 3 | 2 | 1 | 0 | 0 |
| SLC38 | System A & N sodium-coupled neutral amino acid transporter family | 11 | 8 | 6 | 1 | 0 | 1 |
| SLC39 | Metal ion transporter family | 14 | 10 | 10 | 0 | 0 | 0 |
| SLC40 | Basolateral iron transporter family | 1 | 1 | 1 | 0 | 0 | 0 |
| SLC41 | MgtE-like magnesium transporter family | 3 | 1 | 1 | 0 | 0 | 0 |
| SLC42 | Rh ammonium transporter family | 3 | 6 | 5 | 0 | 0 | 1 |
| SLC43 | Na+-independent, system-L like amino acid transporter family | 3 | 3 | 0 | 3 | 0 | 0 |
| SLC44 | Choline-like transporter family | 5 | 4 | 2 | 2 | 0 | 0 |
| SLC45 | Putative sugar transporter family | 4 | 4 | 4 | 0 | 0 | 0 |
| SLC46 | Folate transporter family | 3 | 2 | 2 | 0 | 0 | 0 |
| SLC47 | Multidrug and toxin extrusion (MATE) family | 2 | 2 | 2 | 0 | 0 | 0 |
| SLC48 | Heme transporter family | 1 | 1 | 0 | 1 | 0 | 0 |
| SLC49 | FLVCR-related transporter family | 4 | 4 | 3 | 0 | 0 | 1 |
| SLC50 | Sugar efflux transporters | 1 | 1 | 1 | 0 | 0 | 0 |
| SLC51 | Transporters of steroid-derived molecules | 2 | 1 | 1 | 0 | 0 | 0 |
| SLC52 | Riboflavin transporter family RFVT/SLC52 | 3 | 2 | 2 | 0 | 0 | 0 |
| Total | 398 | 275 | 201 | 51 | 2 | 21 | |
The total number of ‘official members’ (i.e. the members for which an official symbol has been assigned) in each family is shown for human and zebrafish. The number of zebrafish non-duplicated, duplicated and possibly duplicated/not obviously designated genes is also shown. Data have been obtained by GenBank database search on the Reference Zv9 Primary Assembly (July 2013).